Α-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid CICR,Įxtreme statistics describes the distribution of rare events, such as the first ions to find a small target, which are difficult to detect experimentally in biological microdomains. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. European Union’s Horizon 2020 research and innovation program (Marie Sklodowska-Curie Innovative Training Networks, grant number #722053 (EU-GliaPhD)). European Research Council (Consolidator grant #683154) awarded to NR. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: Fondation pour la Recherche Médicale (grant number DEQ20160334882) awarded to DH. Received: ApAccepted: ApPublished: June 4, 2019Ĭopyright: © 2019 Basnayake et al. PLoS Biol 17(6):Īcademic Editor: Franck Polleux, Columbia University, United States of America The present mechanism for which the statistics of the fastest particles arriving at a small target, followed by an amplification, is likely to be generic in molecular transduction across cellular microcompartments, such as thin neuronal processes, astrocytes, endfeets, or protrusions.Ĭitation: Basnayake K, Mazaud D, Bemelmans A, Rouach N, Korkotian E, Holcman D (2019) Fast calcium transients in dendritic spines driven by extreme statistics. The mechanism relies on the asymmetric distributions of RyRs and sarco/ER calcium-ATPase (SERCA) pumps that we predict using a computational model and further confirm experimentally in culture and slice hippocampal neurons. In dendritic spines receiving synaptic inputs, we show here that in the presence of a spine apparatus (SA), which is an extension of the smooth ER, a calcium-induced calcium release (CICR) is triggered at the base of the spine by the fastest calcium ions arriving at a Ryanodyne receptor (RyR). Fast calcium transients (<10 ms) remain difficult to analyse in cellular microdomains, yet they can modulate key cellular events such as trafficking, local ATP production by endoplasmic reticulum-mitochondria complex (ER-mitochondria complex), or spontaneous activity in astrocytes.
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